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KMID : 1161420210240121340
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Journal of Medicinal Food
2021 Volume.24 No. 12 p.1340 ~ p.1343
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Biphasic Effect of Curcuminoids on Oxidation of Postprandial Chylomicrons
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McPherson Peter A. C.
McKenna Niamh
Clare Dilis
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Abstract
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Chylomicrons are large, triglyceride-rich lipoproteins that transport dietary lipids and lipophilic micronutrients through the lymphatic system and into the venous circulation. They therefore represent a valuable means of investigating the bioavailability of a range of bioactive molecules. Curcuminoids have a complex reputation, with most in vitro studies suggesting a beneficial effect (e.g., as an antioxidant), while in vivo work is often, at best, equivocal. We have prepared a curcuminoid extract from fresh turmeric and investigated the transfer of curcuminoids to chylomicrons by rapid ultracentrifugation. We subsequently characterized the chylomicrons in terms of their susceptibility to oxidation. There was a dose-dependent relationship between the curcuminoid level in chylomicrons and decreased levels of preformed lipid hydroperoxides (P?
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KEYWORD
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bioavailability, conjugated dienes, hormesis, inflammation, lipid hydroperoxide, micronutrients, paraoxonase, turmeric
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